Induced Pluripotent Stem Cells in Brain Diseases
Published: 2011-11-23 | ISBN: 9400728158 | PDF | 74 pages | 1.02 MB
Brain diseases be able to have a large impact on patients and companionship, and treatment is often not profitable. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significative breakthrough for regenerative medicine. This promises invalid-specific tissue for replacement therapies, in the same manner with well as disease-specific cells by reason of developmental modeling and drug treatment screening. However, this way faces issues of low reprogramming efficiency, and feeble defined criteria for determining the change of one cell type to another. Cells contain epigenetic "memories" of which they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the sway and determination of cell identity, the epigenetic models that be obliged emerged and the application of iPS small cavity therapy for brain diseases, in uncommon Parkinson's disease and Vanishing White Matter (VWM).
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